SILIQ™ (SIL-EEK) (brodalumab)
- December 30, 2020
- 0
What is SILIQ (Brodalumab)?
SILIQ is a prescription medicine used to treat adults with moderate to severe plaque psoriasis:
- Who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light treatment), and
- Who have not responded or lost response to other systemic therapy
It is not known if SILIQ is safe and effective in children.
What is the most important information I should know about SILIQ?
SILIQ can cause serious side effects. These serious side effects include:
- Suicidal thoughts or behavior have happened in some people treated with SILIQ. Some people have ended their own lives. Your risk of suicidal thoughts and behavior may be increased if you have a history of suicidal thoughts or depression. It is not known if SILIQ causes suicidal thoughts or behavior. Get medical help right away if you or your caregiver notice any of the following symptoms:
- New or worsening depression or anxiety
- Thoughts of suicide, dying, or hurting yourself
- Changes in behavior or mood
- Attempt to commit suicide
- Acting on dangerous impulses
- Serious infections. SILIQ may lower the ability of your immune system to fight infections and may increase your risk of infections. Your healthcare provider will check you for tuberculosis (TB) before starting treatment with SILIQ and may treat you for TB before you begin treatment with SILIQ if you have a history of TB or have active TB. Your healthcare provider should watch you closely for signs and symptoms of infection and TB during and after treatment with SILIQ. Tell your healthcare provider right away if you have an infection or have symptoms of an infection, including:
- Fever, sweats, or chills
- Muscle aches
- Cough
- Shortness of breath
- Sore throat or difficulty swallowing
- Warm, red, or painful skin or sores on your body
- Diarrhea or stomach pain
- Burning when you urinate or urinate more often than normal
- Crohn’s disease. Tell your healthcare provider if you develop diarrhea, painful diarrhea, bloody stools, stomach pain or cramping, sudden or uncontrollable bowel movements, loss of appetite, constipation, weight loss, fever, or tiredness.
- The most common side effects of SILIQ include:
- Joint pain
- Headache
- Tiredness
- Diarrhea
- Mouth or throat pain
- Nausea,
- Injection site reactions
- Flu (influenza)
- Low white blood count (neutropenia)
- Fungal infections of the skin
- Muscle pain
How should I take SILIQ?
- See the detailed “Instructions for Use” that comes with SILIQ for information on how to inject a dose of SILIQ and how to properly store and throw away (dispose of) used SILIQ prefilled syringes.
- Use SILIQ exactly as your healthcare provider tells you to use it.
- Your healthcare provider may stop SILIQ if your plaque psoriasis does not improve within 12 to 16 weeks of treatment.
Important Safety Information
- Do not use SILIQ if you have Crohn’s disease.
- If you are pregnant or plan on becoming pregnant, consult with your healthcare provider.
- Consult with your healthcare provider if your are breastfeeding or plan to breastfeed. It is not known if SILIQ passes into your breast milk.
- Your risk of suicidal thoughts and behavior may be increased if you have a history of suicidal thoughts or depression. It is not known if SILIQ causes suicidal thoughts or behavior
- SILIQ may lower the ability of your immune system to fight infections and may increase your risk of infections.
Ask your healthcare provider if you do not know.
What should I tell my healthcare provider before taking SILIQ?
Before you use SILIQ, tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. And about all of your medical conditions, including if you:
- Have a history of mental problems, including suicidal thoughts, depression, anxiety, or mood problems.
- Have an infection that does not go away or that keeps coming back.
- Have TB or have been in close contact with someone with TB.
- Have recently received or are scheduled to receive an immunization (vaccine). You should avoid receiving live vaccines during treatment with SILIQ.
- Are pregnant or plan to become pregnant. It is not known if SILIQ can harm your unborn baby. If you are pregnant or plan on becoming pregnant, consult with your healthcare provider
- Are breastfeeding or plan to breastfeed. It is not known if SILIQ passes into your breast milk.
General information about SILIQ
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use SILIQ for a condition for which it was not prescribed. Do not give SILIQ to other people even if they have the same symptoms that you have. It may harm them.
What are the ingredients in SILIQ?
Active ingredient: Brodalumab
Other ingredient:
