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IDHIFA®
(eyed-HEE-fuh)
(Enasidenib)

Chemotherapy 

Have a Question ?

IDHIFA®
(eyed-HEE-fuh)
(Enasidenib)

Chemotherapy

Have a Question ?

What is IDHIFA (Enasidenib)?

IDHIFA is a prescription medicine used to treat people with acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation whose disease has come back or has not improved after previous treatment(s).

It is not known if IDHIFA is safe and effective in children.

What is the most important information I should know about IDHIFA?

IDHIFA can cause serious side effects. These serious side effects include:

  • Differentiation Syndrome. Differentiation syndrome is a condition that affects your blood cells which may be life-threatening or lead to death if not treated. Differentiation syndrome has happened within 10 days and up to 5 months after starting IDHIFA. Call your healthcare provider or go to the nearest hospital emergency room right away if you develop any of the following symptoms of differentiation syndrome while taking IDHIFA:
  • Fever
  • Cough
  • Shortness of breath
  • Swelling of arms and legs
  • Swelling around neck, groin, or underarm area
  • Bone pain
  • Fast weight gain (greater than 10 pounds within a week)
  • The most common side effects of IDHIFA include:
  • Nausea
  • Diarrhea
  • Decreased appetite
  • Vomiting
  • Jaundice

Tell your healthcare provider if you have any changes to the color of your skin or the whites of your eyes.

How should I take IDHIFA?

  • Take IDHIFA exactly as your healthcare provider tells you to.
  • Take IDHIFA 1 time a day at the same time each day.
  • Swallow IDHIFA tablets whole. Do not chew or split the tablet.
  • Swallow IDHIFA with 8 ounces (one cup) of water.
  • IDHIFA can be taken with or without food.
  • If you miss a dose of IDHIFA or vomit after taking a dose of IDHIFA, take the dose of IDHIFA as soon as possible on the same day. Then take your next dose the next day at your regularly scheduled time. Do not take 2 doses at the same time to make up for the missed dose.
  • Your healthcare provider should do blood tests to check your blood counts before you start IDHIFA treatment and at a minimum of every 2 weeks for at least the first 3 months during treatment to check for side effects.
Nucleic Acid Diagnostic kit

Important Safety Information

  • IDHIFA can cause harm to your unborn baby if taken during pregnancy
  • Females who are able to become pregnant and who take IDHIFA should use effective birth control (contraception) during treatment with IDHIFA and for at least 1 month after your last dose of IDHIFA.
  • Males who have female partners that are able to become pregnant should use effective birth control during treatment with IDHIFA and for at least 1 month after your last dose of IDHIFA.
  • It is not known if IDHIFA passes into your breast milk. You should not breastfeed during your treatment with IDHIFA and for at least 1 month after your last dose of IDHIFA.
  • If you miss a dose of IDHIFA or vomit after taking a dose of IDHIFA, take the dose of IDHIFA as soon as possible on the same day. Then take your next dose the next day at your regularly scheduled time. Do not take 2 doses at the same time to make up for the missed dose.

Ask your healthcare provider if you do not know.

What should I tell my healthcare provider before taking IDHIFA ?

Before taking IDHIFA, tell your healthcare provider about all of your medical conditions, including if you:

  • Are pregnant or plan to become pregnant. IDHIFA can cause harm to your unborn baby if taken during pregnancy
  • If you are able to become pregnant, your healthcare provider will do a pregnancy test before you start taking IDHIFA.
  • Females who are able to become pregnant and who take IDHIFA should use effective birth control (contraception) during treatment with IDHIFA and for at least 1 month after your last dose of IDHIFA.
  • Males who have female partners that are able to become pregnant should use effective birth control during treatment with IDHIFA and for at least 1 month after your last dose of IDHIFA.
  • IDHIFA may affect how hormonal contraceptives work and may cause them to not work as well.
  • Talk to your healthcare provider about birth control methods that may be right for you while taking IDHIFA.
  • IDHIFA may cause fertility problems in females and males, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.
  • Are breastfeeding or plan to breastfeed. It is not known if IDHIFA passes into your breast milk. You should not breastfeed during your treatment with IDHIFA and for at least 1 month after your last dose of IDHIFA.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

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General information about IDHIFA

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not take IDHIFA for conditions for which it was not prescribed. Do not give IDHIFA to other people, even if they have the same symptoms you have. It may harm them.

What are the ingredients in IDHIFA ?

Active ingredient: Enasidenib

Other ingredient: Colloidal silicon dioxide, hydroxypropyl cellulose, hypromellose acetate succinate, iron oxide yellow, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, sodium lauryl sulfate, sodium starch glycolate, talc, and titanium dioxide

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