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ABRAXANE®
(ah-BRAKS-ane)
Paclitaxel protein-bound particles for injectable suspension(albumin-bound)

Chemotherapy 

Have a Question ?

ABRAXANE®
(ah-BRAKS-ane)
Paclitaxel protein-bound particles for injectable suspension(albumin-bound)

Chemotherapy

Have a Question ?

What is ABRAXANE?

ABRAXANE is a prescription medicine used to treat:

  • advanced breast cancer in people who have already received certain other medicines for their cancer.
  • advanced non-small cell lung cancer (NSCLC), in combination with carboplatin in people who cannot be treated with surgery or radiation.
  • advanced pancreatic cancer, when used in combination with gemcitabine as the first medicine for advanced pancreatic cancer.

It is not known if ABRAXANE is safe or effective in children.

How will I receive ABRAXANE?

  • Your healthcare provider will prescribe ABRAXANE in an amount that is right for you.
  • Your healthcare provider may give you certain medicines to help prevent allergic reactions if you have had an allergic reaction to ABRAXANE in the past.
  • ABRAXANE will be given to you by intravenous (IV) infusion into your vein.
  • Your healthcare provider should do blood tests regularly during treatment with ABRAXANE.
  • Your healthcare provider may stop your treatment, delay your treatment, or change your dose of ABRAXANE if you have certain side effects.

What are the possible side effects of ABRAXANE?

ABRAXANE may cause serious side effects, including:

  • Severe decreased blood cell counts. ABRAXANE can cause a severe decrease in neutrophils, a type of white blood cell which helps fight infections, and blood cells called platelets which help to clot blood. Your healthcare provider will check your blood cell count during your treatment with ABRAXANE.
  • Severe nerve problems (neuropathy). Tell your healthcare provider if you have numbness, tingling, pain, or weakness in your hands or feet.
  • Severe infection (sepsis). If you receive ABRAXANE in combination with gemcitabine, infections can be severe and lead to death. Tell your healthcare provider right away if you have a fever (temperature greater than 100.4° F) or develop signs of infection.
  • Lung or breathing problems. If you receive ABRAXANE in combination with gemcitabine, lung or breathing problems may be severe and can lead to death. Tell your healthcare provider right away if you suddenly get a dry cough that will not go away or shortness of breath.
  • Severe allergic reactions. Severe allergic reactions are medical emergencies that can happen in people who receive ABRAXANE and can lead to death. You may have an increased risk of having an allergic reaction to ABRAXANE if you are allergic to other taxane medicines. Your healthcare provider will monitor you closely for allergic reactions during your infusion of ABRAXANE. Tell your healthcare provider right away if you get any of these signs of a serious allergic reaction: trouble breathing, sudden swelling of your face, lips, tongue, throat, or trouble swallowing, hives (raised bumps), rash, or redness all over your body.
  • The most common side effects of ABRAXANE in people with breast cancer include:
  • hair loss
  • numbness, tingling, pain, or weakness in the hands or feet
  • tiredness
  • changes in your liver function tests
  • nausea
  • diarrhea
  • infections
  • decreased white blood cell count
  • abnormal heartbeat
  • joint and muscle pain
  • low red blood cell count (anemia). Red blood cells carry oxygen to your body tissues. Tell your healthcare provider if you feel weak, tired, or short of breath.
  • The most common side effects of ABRAXANE in people with non-small cell lung cancer include:
  • low red blood cell count (anemia)
  • decreased platelet cell count
  • numbness, tingling, pain, or weakness in the hands or feet
  • tiredness
  • decreased white blood cell count
  • hair loss
  • nausea
  • The most common side effects of ABRAXANE in people with pancreatic cancer include:
  • decreased white blood cell count
  • numbness, tingling, pain, or weakness in the hands or feet
  • hair loss
  • diarrhea
  • vomiting
  • rash
  • tiredness
  • nausea
  • swelling in the hands or feet
  • fever
  • decreased appetite
  • signs of dehydration including thirst, dry mouth, dark yellow urine, decreased urine, headache, or muscle cramps

Tell your healthcare provider if you have vomiting, diarrhea, or signs of dehydration that does not go away. ABRAXANE may cause fertility problems in males and females, which may affect your ability to have a child. 

Talk to your healthcare provider if this is a concern for you. These are not all of the possible side effects of ABRAXANE. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

 

Nucleic Acid Diagnostic kit

Important Safety Information

You should not receive ABRAXANE if:

  • your white blood cell count is below 1,500 cells/ mm3.
  • you have had a severe allergic reaction to ABRAXANE
  • See the end of this leaflet for a complete list of ingredients of ABRAXANE

Before you receive ABRAXANE, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver or kidney problems
  • had a prior allergic reaction to a taxane
  • are pregnant or plan to become pregnant. ABRAXANE can harm your unborn baby.

    Females who are able to become pregnant:
    o Your healthcare provider will check to see if you are pregnant before you start treatment with ABRAXANE.
    o You should not become pregnant during your treatment and for at least six months after the last dose of ABRAXANE.
    o You should use effective birth control (contraception) during your treatment and for at least six months after the last dose of ABRAXANE. Talk to your healthcare provider about birth control methods you can use during this time.

    Males with a female sexual partner who can become pregnant:
    o ABRAXANE can harm the unborn baby of your partner.
    o You should not father a child during your treatment and for at least three months after the last dose of ABRAXANE.
    o You should use effective birth control (contraception) during your treatment and for at least three months after the last dose of ABRAXANE.

  • are breastfeeding or plan to breastfeed. Do not breastfeed during your treatment and for two weeks after the last dose of ABRAXANE.
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Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list to show your healthcare provider and pharmacist when you get a new medicine.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. 

General information about the safe and effective use of ABRAXANE.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. You can ask your healthcare provider or pharmacist for information about ABRAXANE that is written for health professionals.

What are the ingredients in ABRAXANE?

Active ingredient: paclitaxel (bound to human albumin). 

Other ingredient: human albumin (containing sodium caprylate and sodium acetyltryptophanate).

Please see full Prescribing Information for additional Important Safety Information.

Associated Conditions

Advanced Cervical Cancer
Advanced Head and Neck Cancer
Advanced Ovarian Cancer
Advanced Soft Tissue Sarcoma
Esophageal Cancers
Fallopian Tube Cancer
Kaposi’s sarcoma
Locally Advanced Non-Small Cell Lung Cancer
Malignant Neoplasm of Stomach
Malignant Peritoneal Neoplasm
Metastatic Bladder Cancer
Metastatic Breast Cancer
Metastatic Melanoma
Metastatic Non-Small Cell Lung Cancer
Non-Small Cell Lung Carcinoma (NSCLC)
Ovarian Cancer
Pancreatic Adenocarcinoma Metastatic
Advanced Bladder cancer
Advanced Thymoma
Metastatic Penile cancer
Refractory Small cell lung cancer
Refractory Testicular germ cell cancer

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