FDA inobvumidza Keytruda pembrolizumab seyokutanga mutsara immunotherapy yekenza yepamusoro yekenza

Iyi ndiyo ye9th FDA mvumo yemishonga inotsigirwa neKisimuka Kumusoro kweCancer research.

Iyo FDA munguva pfupi yapfuura yakabvumidza iyo immunotherapy drug pembrolizumab semutsara wekutanga kurapwa kwevarwere vane mamwe marudzi e yakakwira colorectal cancer. Uku ndiko kubvumidzwa kwe9th FDA kunotsigirwa neStand Up To Cancer® (SU2C) research.

Varwere vachangobva kuongororwa kuti vane yepamusoro kana metastatic microsatellite kusagadzikana-yakakwira (MSI-H) or mismatch kugadzirisa kushomeka (dMMR) kenza yakajeka kare ingadai yakatemwa pembrolizumab chete mushure mekuneta kwakajairwa chemotherapy kurapwa.

Iyo FDA yakabvumidza pembrolizumab, inozivikanwawo pasi pezita rezita Keytruda, seyokutanga-kurapwa kurapwa kwe metastatic MSI-H-dMMR kenza yakajeka zvichibva pamhedzisiro yekutanga kubva muchikamu chechitatu chekiriniki yekuyedzwa, iyo yaibhadharwa mari nechikwereti cheSU2C.

"Kana ichienzaniswa neyechinyakare kurapwa, pembrolizumab yaive yepamusoro ine mashoma mhedzisiro mhedzisiro yeMSI-H-dMMR colorectal varwere," akadaro Luis A. Diaz, MD, Musoro weDhipatimendi reSolid Tumor Oncology paChirangaridzo Sloan Kettering Cancer Center uye mutungamiri we SU2C Colorectal Cancer Kurota Chikwata, iyo yakaita ongororo iyi. "Kune mamwe makondombera akasimba muvanhu vakuru nevana vane izvi zvakafanana MSI-H-dMMR kuremara, saka tsvagiridzo yedu inogona zvakare kuve nemagadzirirwo emamwe marudzi ekenza."

Around 4-5% yemastastatic cancer tumors ane MSI-H-dMMR biomarkers, izvo zvinokonzeresa nekusagona kwemasero kugadzirisa zvikanganiso zvakaitwa panguva yekuparadzaniswa kwemaseru uye zvinogona kutungamira mukuwedzera bundu kukura.

Chidzidzo ichi chaisanganisira 307 MSI-H-dMMR varwere vegomarara vari munyika makumi maviri nematatu vaibatwa pamwe ne pembrolizumab kana standard chemotherapy. Pembrolizumab zvinangwa uye zvinodzivirira protein inonzi PD-23 iyo inogona kudzivirira maseru ekudzivirira anonzi maT seli kubva pakubvisa maseru ekenza zvinobudirira.

Dr. Diaz nechikwata chake vakaona kuti MSI-H-dMMR colorectal cancer varwere vanorapwa nepembrolizumab havana kuona kenza yavo ichipararira kwemwedzi wepakati 16.5, zvichienzaniswa nevarwere vanorapwa neyakajairwa chemotherapy avo vakaona mamota avo achikura mushure memwedzi wepakati 8.2. Varwere vanogamuchira chemotherapy yakajairwa vaivewo nematambudziko akakomba pane varwere vanogamuchira pembrolizumab. Mhedzisiro yekudzidza inoguma zvakabudiswa muNew England Chinyorwa cheMishonga muna Zvita 2, 2020.

"Stand Up To Cancer Colorectal Cancer Dream Team yakaita mupiro wakakosha kune yakagadziridzwa nzira yekurapa yeMSI-H-dMMR colorectal varwere," akadaro weNobel mukwikwidzi Phillip A. Sharp, PhD, sachigaro weStand Up To Cancer Scientific Advisory Committee uye an Institute professor paDavid H. Koch Institute for Integrative Cancer Research paMassachusetts Institute of Technology. "Uyu muenzaniso wakanaka wekuti kubatana kwekutsvagirana kweCancer kusimudzira kune hupenyu hwevarwere vegomarara."

Colorectal cancer ndiyo chechipiri chinonyanya kukonzera kenza kufa pakati pevarume nevakadzi veAmerica vakasanganiswa uye vangangoita 148,000 vokuAmerica ichagamuchira kuongororwa patsva kwekenza yemukondoni kana rectal muna 2020. Kunyange hazvo colorectal cancer cancer mitengo yakaderera zvakanyanya nekuda kwekuwedzera kuongorora uye kugadzirisa pakurapa, nezve 1 muvatatu vakuru vane makore makumi mashanu kana kudarika usawane kuongororwa kwakurudzirwa. Mitsva mitsva yekenza yakajeka iri zvichiitika pamwero unokura pakati pevakuru uye vepakati-vakuru vakuru muUS, ine huwandu hwezviitiko zvecolorectal cancer muvanhu vari pasi pemakumi mashanu vanotarisirwa kupetwa kaviri kubudikidza 2030.

Sezvo colorectal cancer inoramba ichikanganisa zvisingaite vanhu vane ruvara
(Vanhu vatema vane mwero wepamusoro yekenza yakajeka yekenza yedzinza kana dzinza muUS), kuvandudzwa kwekutarisa uye kunyatso kujeka uye kurapwa kwakanangwa kunofanirwa kusvika kune vese varwere. SU2C yakazivisa Health Equity Initiative munaNdira 2020. Chirongwa ichi chinoda kuti zvikwata zvese zvenguva yemberi zvinotsvaga mari yeKusimukira Kumusoro yeCancer kugadzirisa kutsvaga nekuchengetwa kwevarwere vanobva kumarudzi akasiyana-siyana uye madzinza uye nharaunda dzisina kuchengetedzwa kuti vavandudze kutora chikamu kwakasiyana mumakenza emakiriniki ekuedzwa. Ichi chirongwa chinosanganisira zvakare kubatana pamwe nemapoka ekukurudzira uye maindasitiri nevatsigiri vekambani kufambisira mberi kutsvagurudza nekuedza kweruzhinji kuziva

Iyo SU2C Colorectal Cancer Yekurota Timu inotungamirwa neYakamira Kumusoro kuCancer sainzi mudiwa, iyo American Association yeCancer Kutsvaga.

Mirabai Vogt-James
310-739-5576