Biocon chinodhaka che COVID 19 ALZUMAb® (Itolizumab)

Biocon's Mushonga weCOVID-19: ALZUMAb® (Itolizumab)

Denda reCCIDID-19 rakanganisa zvakanyanya pasirese, zvichikonzera kurasikirwa kukuru kwehupenyu uye kukanganisa kwakawanda kwehupfumi. Kudiwa kwemishonga inoshanda uye majekiseni ekurwisa hutachiona kwakakosha. Biocon, kambani inotungamira biopharmaceutical, yakagadzira mushonga unonzi ALZUMAb® (Itolizumab) kurapa COVID-19.

Chii chinonzi ALZUMAb® (Itolizumab)?

ALZUMAb® (Itolizumab) mushonga wemonoclonal antibody wakashandiswa muIndia kwemakore akati wandei kurapa psoriasis, chirwere chisingaperi cheganda. Muna Chikumi 2020, iyo Drug Controller General yeIndia (DCGI) yakabvumidza kushandiswa kweALZUMAb® (Itolizumab) yekushandiswa kwekukurumidzira muCOVID-19 varwere vane pakati kusvika kune yakanyanya acute respiratory distress syndrome (ARDS).

Ko ALZUMAb® (Itolizumab) inoshanda sei?

ALZUMAb® (Itolizumab) inoshanda nekusunga kune imwe protein inodaidzwa kuti CD6 inoburitswa pamusoro peT cells, rudzi rwesero rekudzivirira zvirwere. Nekusunga kuCD6, ALZUMAb® (Itolizumab) inodzivirira kuvhurwa uye kuwanda kweT masero, izvo zvinogona kutungamira kune yakawandisa immune system kupindura kana cytokine dutu muCOVID-19 varwere. Dutu re cytokine rinogona kukonzera kukuvara kwakanyanya kwemapapu uye kutadza kufema, zvichikonzera huwandu hwekufa kwevarwere veCOVID-19.

Miedzo yemakiriniki yeALZUMAb® (Itolizumab)

Biocon yakaita Phase II kiriniki yekuyedza yeALZUMAb® (Itolizumab) muCOVID-19 varwere vane pakati kusvika kune yakanyanya ARDS. Muedzo wakanyoresa varwere makumi matatu, avo makumi maviri vakagamuchira ALZUMAb® (Itolizumab) uye gumi vakagamuchira mwero wekutarisirwa. Mhedzisiro yemuyedzo yakaratidza kuti ALZUMAb® (Itolizumab) yakaderedza zvakanyanya huwandu hwekufa muvarwere veCCIDID-30 vane pakati kusvika kune yakanyanya ARDS. Kufa kwevanhu muboka reALZUMAb® (Itolizumab) kwaiva 20%, zvichienzaniswa ne10% muhutano hweboka rekuchengetedza.

Uye zvakare, ALZUMAb® (Itolizumab) yakavandudza oxygenation uye yakaderedza kuzvimba muvarwere veCOVID-19. Mushonga wacho wakanyatsobvumirwa pasina zviitiko zvakakosha zvakashata zvakashumwa.

Iyo Phase II yekiriniki yekuyedza yeALZUMAb® (Itolizumab) yakateverwa nechikamu chechitatu chekiriniki kuyedza, iyo yakanyoresa varwere makumi matatu vane mwero kusvika kune yakanyanya COVID-30. Zvakabuda muyedzo yePhase III zvakamirira.

mhedziso

ALZUMAb® (Itolizumab) yakaratidza mhedzisiro inovimbisa mumakiriniki miedzo yekurapa varwere veCCIDID-19 vane mwero kusvika kune yakanyanya ARDS. Mushonga unoshanda nekusunga kuCD6 uye kudzivirira kuvhurwa uye kuwanda kweT masero, izvo zvinogona kukonzera dutu re cytokine muvarwere veCOVID-19. ALZUMAb® (Itolizumab) yakabvumidzwa kushandiswa kwechimbichimbi muIndia, uye kuchengetedzeka kwayo uye kushanda kwayo kuri kuongororwa mumiyedzo yekiriniki inoenderera. Kana mhedzisiro yemuyedzo wePhase III yakanaka, ALZUMAb® (Itolizumab) inogona kuve yakakosha kurapwa sarudzo yevarwere veCOVID-19.