Mankhwala a Biocon a COVID 19 ALZUMAb® (Itolizumab)

MATENDA A COVID-19

Mankhwala a Biocon a COVID-19: ALZUMAb® (Itolizumab)

Mliri wa COVID-19 wakhudza kwambiri dziko lapansi, zomwe zapangitsa kuti anthu awonongeke kwambiri komanso kusokonekera kwachuma. Kufunika kwa chithandizo chamankhwala chogwira ntchito komanso katemera wothana ndi kachilomboka ndikofunikira. Biocon, kampani yotsogola ya biopharmaceutical, yapanga mankhwala otchedwa ALZUMAb® (Itolizumab) kuchiza COVID-19.

Kodi ALZUMAb® (Itolizumab) ndi chiyani?

ALZUMAb® (Itolizumab) ndi mankhwala opangidwa ndi anthu omwe akhala akugwiritsidwa ntchito ku India kwa zaka zingapo pochiza psoriasis, matenda osatha akhungu. Mu June 2020, Drug Controller General of India (DCGI) idavomereza kugwiritsa ntchito ALZUMAb® (Itolizumab) kuti igwiritsidwe ntchito mwadzidzidzi kwa odwala a COVID-19 omwe ali ndi matenda apakati mpaka aacute kupuma movutikira (ARDS).

Kodi ALZUMAb® (Itolizumab) imagwira ntchito bwanji?

ALZUMAb® (Itolizumab) imagwira ntchito pomanga puloteni inayake yotchedwa CD6 yomwe imawonekera pamwamba pa ma T cell, mtundu wa selo loteteza thupi. Pomanga ku CD6, ALZUMAb® (Itolizumab) imalepheretsa kuyambika ndi kuchuluka kwa ma T cell, zomwe zitha kubweretsa kuyankha kwamphamvu kwa chitetezo chamthupi kapena mkuntho wa cytokine mwa odwala a COVID-19. Mphepo yamkuntho ya cytokine imatha kuwononga kwambiri m'mapapo komanso kulephera kupuma, zomwe zimapangitsa kuti anthu azifa kwambiri mwa odwala a COVID-19.

Mayesero azachipatala a ALZUMAb® (Itolizumab)

Biocon idachita mayeso azachipatala a Phase II a ALZUMAb® (Itolizumab) mwa odwala a COVID-19 omwe ali ndi ARDS yocheperako mpaka yowopsa. Mlanduwu unalembetsa odwala 30, omwe 20 adalandira ALZUMAb® (Itolizumab) ndipo 10 adalandira chisamaliro choyenera. Zotsatira za mayesowo zidawonetsa kuti ALZUMAb® (Itolizumab) idachepetsa kwambiri chiwopsezo chaimfa mwa odwala a COVID-19 omwe ali ndi ma ARDS ochepera mpaka ovuta. Chiwopsezo cha kufa kwa gulu la ALZUMAb® (Itolizumab) chinali 15%, poyerekeza ndi 40% pagulu la chisamaliro choyenera.

Kuphatikiza apo, ALZUMAb® (Itolizumab) idawongolera mpweya komanso kuchepetsa kutupa kwa odwala a COVID-19. Mankhwalawa adalekerera bwino popanda zovuta zazikulu zomwe zidanenedwa.

Mayesero azachipatala a Phase II a ALZUMAb® (Itolizumab) adatsatiridwa ndi mayeso azachipatala a Phase III, omwe adalembetsa odwala 30 omwe ali ndi COVID-19 yocheperako. Zotsatira za mayeso a Phase III zikudikirira.

Kutsiliza

ALZUMAb® (Itolizumab) yawonetsa zotsatira zabwino pamayesero azachipatala pochiza odwala a COVID-19 omwe ali ndi ma ARDS ochepera mpaka ovuta. Mankhwalawa amagwira ntchito pomanga ku CD6 ndikuletsa kuyambitsa ndi kuchuluka kwa ma T cell, omwe angayambitse mkuntho wa cytokine mwa odwala a COVID-19. ALZUMAb® (Itolizumab) yavomerezedwa kuti igwiritsidwe ntchito mwadzidzidzi ku India, ndipo chitetezo chake ndi mphamvu zake zikuphunziridwa m'mayesero opitilira azachipatala. Ngati zotsatira za mayeso a Phase III zili zabwino, ALZUMAb® (Itolizumab) ikhoza kukhala njira yothandiza kwambiri kwa odwala a COVID-19.